Mods suddenly disabled (I think)

[Coffe_Kanon]

Ok, so I haven't been playing FO4 for some time, so I decided to give it a go again.

When loading my most recent save I get an error message saying that the save file requests resources that are no longer present. I try loading it and, since I used to have the Darker Nights mod I immediately noticed that the mod has been disabled somehow because it was night time in the game and it was way too bright for Darker Nights to be in effect.

I'm not very experienced at fixing mods. I remember when I installed the game the first time to do some changes to the ini files as per a guide here on nexus mods. I also remember doing yet another change to the ini files later on because that guide got updated with new stuff.

I also tried updating a few mods through the NMM awhile back (a process that was quite troublesome because it seems I had to manually disable old versions of mods, download, install and enable newer versions of those same mods). A simple "online update"-function that doesn't require the user to do all the legwork would've been nice. :P

I also find some threads here saying that some people experience something similar to my problems (either with mods not working or the game simply crash), and that the only remedy is to uninstall the entire game and all mods and NMM.

If push comes to shove and I have no choice but to do that, can I back up my save files, re-install everything (the game, NMM, mods I used etc.) and resume playing like before, or will my save files be corrupted?

Thanks on beforehand for assistance.