SKSE memory patch not working

[legoryan717]

So I've beguyn a new playthrough of Skyrim and did all the mod testing and thoguht I had the game stable, but I get random CTD's in random areas that I have to avoid at that time because something makes them ctd, but after mod testing I discoverd its the memory blocks, no matter how high I raise them, I find that I crash when they hit 250, its really starting to annoy me, I'm currently crashin as I prpare to battle for Markarth, no mod confilicts, just too many actors on screen causing lag and a CTD, any help is really appreciated as this is my favourite game and I love the charecter I am currently roleplaying as

Thanks in advance
Ryan