SkyUI No Effect

[OneShotPaddy4]

Setup:

Latest version of Skyrim SE from Steam, with latest version of SKSE64 and Vortex.

Problem:

• Original - Skyrim Special Edition would act as though I had no mods installed, even ignoring the Alternate Start mod. Eventually I discovered that it would work if I enabled the mods in the in-game mod manager (hereby referred to in this thread as SEMM) . However, this has led me to my current problem.
  
• Current - SkyUI is constantly disabled by SEMM. This would be fine, if enabling it in SEMM worked. However, even when I enable it, restart and double-check, then launch the game, there is no effect. This is the case despite SkyUI being active in SEMM and Vortex.

Tried:

• Checking plugin and mod list in Vortex
• Ensured the plugins.txt and loadorder.txt are properly generated by Vortex and NOT read-only
• Fresh installs of everything more times than I can count (going so far as to shift-delete all the folders, including in AppData).
• Just using Vortex and NOT SEMM (this was suggested to me despite me explaining my situation, please don't respond with this, I am well aware that I don't want to be using SEMM, I'm TRYING to not use it, that's the point of this post).

 

TidBits:

• I have my AppData folder (most of my non-essential Windows folders, including MyDocuments) on my 2nd HDD. Windows recognizes these locations as the new default and has worked fine. ALL GAME DATA is on one HDD.
• I have been working on this for about 3 days and thus my frustration is mounting, so please excuse my frustration. I've been put through the wringer of online advice in various threads on multiple sites, as well as some less-than-polite folks in this forum too (if you're reading this, you know well who you are, don't even bother responding).

 

Modlist:

# Automatically generated by Vortex
*Lanterns Of Skyrim - All In One - Main.esm
*Unofficial Skyrim Special Edition Patch.esp
*CBBE.esl
*PickUpBooksSimple.esl
*Immersive Wenches.esp
*SkyUI_SE.esp
*SMIM-SE-Merged-All.esp
*BlackthornManor.esp
*Solitude Expansion.esp
*Blackthorn_SRB&LOS.esp
*Skyrim Better Roads - The Rift.esp
*BetterDocks-MP-DLC-Compatible.esp
*Hothtrooper44_Armor_Ecksstra.esp
*Skyrim Better Roads - EastMarch.esp
*Hothtrooper44_ArmorCompilation.esp
*TheScarlett.esp
*Dr_Bandolier.esp
*Skyrim Better Roads and Bridges - All In One - Merged.esp
*Bijin Wives.esp
*XPMSE.esp
*iHUD.esp
*AMatterOfTime.esp
*Simple AUA.esp
*True Scholar.esp
*AmazingFollowerTweaks.esp
*Immersive Weapons.esp
*Bijin NPCs.esp
*Bijin Warmaidens.esp
*AFT_ManagedFollowerBoost.esp
*AFT_NoFriendlySpellDamage.esp
*Cloaks.esp
*Skyrim Better Roads - Winterhold.esp
*SE - Better Docks Patch.esp
*Immersive Patrols II.esp
*SofiaFollower.esp
*Cloaks - Dawnguard.esp
*Cloaks - USSEP Patch.esp
*FNIS.esp
*KS Hairdo's.esp
*Immersive Wenches -KS hairs- Patch.esp
*GoOnAhead.esp
*BetterDocks_TheScarlett_Patch.esp
*Skyrim Flora Overhaul.esp
*ForgottenCity.esp
*Relationship Dialogue Overhaul.esp
*RDO - AFT v1.66 Patch.esp
*RDO - USSEP Patch.esp
*Alternate Start - Live Another Life.esp
*Open Cities Skyrim.esp
*OCS - Immersive Armors Patch.esp
*SE -OC Patch 2.esp
*RDO - CRF + USSEP Patch.esp

[wfandrews]

Are you launching SSE with SKSE64?

[InsaneInsomniac]

assuming you are using NMM as your main launch for the mods, have you made sure all the mods are checked on the plugins page? NMM has occasionally given me issues where it says my mods are active, but when the game starts they aren't actually loading cause the plugin is turned off