Can't talk with most npc's

[Excoter]

Now got enb sorted out and went to start new game from very beginning... and npc's wont talk again. =(

 

 

Edit: Toggle this TAI with console wont fix anything for me.

Edited February 14, 2019 by Mikki2016

[Excoter]

Now using cheat fast travel I was able to open Piper to talk, after I force trigger DC gate to open.

 

But Trashcan Carla keeps being bugged, she wont say more than "huh?" and game wont let me to say proper lines of first encounter conversation.

 

 

EDIT: After testing around the bug is causing caravan traders Carla, Cricket and Lucas not to talk.. Doc Weathers acts ok.

Edited February 15, 2019 by Mikki2016

[Excoter]

This is gettin weird and frustrading, I just can't find the cause for this stupid bug.

[0vermind]

This is gettin weird and frustrading, I just can't find the cause for this stupid bug.

 

Have you been able to find a cause and fix? This bug has been annoying me for days!

[DanteWrath]

So as with anything, it's entirely possible for multiple similar (or even seemingly identical) bugs to appear with a variety of causes, so while I've experienced a 'can't initiate dialogue with some NPCs' bug, I can't say with any certainty that my findings will apply to you.
For me, the bug effects most NPCs in diamond city, so if these NPCs are not an issue for you (e.g. if you can trade with all vendors there without issue) then there's a good chance we're experiencing different, but similar bugs.

With that out of the way, in my case, this bug is definitely caused by mods, but diagnosing which mod (or mods) cause it would be extremely time consuming for two reasons.
Firstly, the bug does not resolve by uninstalling your mods, and secondly this bug actually starts at character creation, but since it doesn't effect all NPCs it's entirely possible to get as far as diamond city before realizing this is a problem.

Unfortunately, I've spent a lot of time trying to fix this bug over the years (I'v experienced it multiple times now) and as far as I can tell, once it occurs there's no way to fix it.
That said, the fact this bug appears at character creation is important when it comes to avoiding the issue.
In my testing, the bug will never occur when you install a mod midway through a playthrough, it'll only appear when you start a new character with whatever mods are causing this.
In my case at least, I can have two characters with the exact same load order, one in which I had the mods installed at character creation, and one in which I enabled them afterwards, and every time I've tried this it's only the former that has the bug.

With that in mind, you can avoid this issue by starting the game with only mods that absolutely require a fresh character installed (whether that be because it effects the prologue, such as alternative start mods, or simply because the mod author recommends using it on a fresh character).
After creating your character at the mirror (I recommend saving your character as a preset), immediately save (I think the game makes a save at this time anyway) and use the console command "coc diamondcityorigin" to teleport to diamond city, and attempt to talk to Takahashi.
Every single time I've had this bug, Takahashi has been one of the NPCs unable to initiate dialogue, if this is the case then you have the bug and need to uninstall some mods and create a new character.
Otherwise reload your prologue save, complete the prologue and then install the rest of your mods.
To be safe, it's probably worth teleporting to diamond city again after installing any new mods to check everything still works, but as I said in my case it's never been an issue after character creation.

It's a massive pain, but it beats getting all the way to diamond city before discovering the issue.

Edited March 14, 2020 by DanteWrath

[DeviantRaccoonus]

So I just had a similar issue and saw this post, I resolved my issue by going to my companion (Dogmeat in this case) and talking to them, telling him to stay and then exited the interaction with him by pressing escape. Afterwards I could talk to NPCs normally again. It was if my talking to Dogmeat earlier bugged or the game thought I was in command mode to order him around, although no indication of it on my crosshairs.
Give a it a try, nothing to lose.

[ElitePug9]

So I just had a similar issue and saw this post, I resolved my issue by going to my companion (Dogmeat in this case) and talking to them, telling him to stay and then exited the interaction with him by pressing escape. Afterwards I could talk to NPCs normally again. It was if my talking to Dogmeat earlier bugged or the game thought I was in command mode to order him around, although no indication of it on my crosshairs.

Give a it a try, nothing to lose.

I was about to try this but I accidentally dismissed piper before this so now I'm soft locked