Mods not working for New Vegas

[HuggableCube]

Hey guys and dolls,

So I'm modding New Vegas on my new machine and reinstalling the mods I used to use. I installed the basic tools like NVSE, 4GIG etc as usual (not using vortex).

 

However when it comes to downloading and installing mods with Vortex non of them seem to take effect. I've installed and deployed them with seemingly no problem but when I boot up the game there's no change. I didn't have this problem with previous nexus mod manager, everything was simple back then. For example I'm just trying to get the Fallout Character Overhaul to work and I've done all the pre-requisit stuff and it's installed, enabled and deployed (what ever that means) but it isn't doing anything in game.