Ok guys, I've done lots of reading to figure this out, and I'm posting it here only because I'm hoping Tannin has an answer to give if he wants it, or that others find it on google when they thing Vortex is being the issue when it's not.
If you're using the steam version of the GOTY Fallout 3, you have to download GamesForWindowsLive disabler, here on nexusmods, and activate it! That's step 1! If you DO NOT do that, you will have big fonts, or you will crash as soon as the game loads the DUI head in the bottom left of the screen! IF you have crashing it's because of your ini setup (you didn't do that wrong, you just didn't activate GFWL disabler). If you didn't edit the fonts in your fallout.ini in the my documents/fallout 3 folder, then you have large fonts and are frustrated beyond belief. THAT IS WHY. Activate GFWL disabler, THEN insert this into your fonts. Delete the old font content first in that .ini
There you go, copy, paste/replace the old, save, exit notepad, launch using FOSE_Loader through vortex and that's it. You're welcome.
If this post isn't allowed here, PLEASE move it somewhere that google will find it, I'm hoping someone else doesn't need 3+ hours of searching to figure it out................ After trying everything else I finally figured this out WITHOUT GOOGLE. >.<