In response to post #37122990. #37123005 is also a reply to the same post. Having pretty much the same problem, except I have much fewer mods and even less plugins. Mostly its just textures. It happened right after the "hot fix" update to the beta, before that I had no issues. I have made sure that I'm using the latest version of NMM and that it activates my plugins with an *. I have already tried reinstalling everything and deleted my previous save, incase it had become corrupted and started a new character. Everything seemed to work fine until I start doing "main" missions. I'm able to load the last save, which is inside the place you meet Preston and his group for the first time, but when I attempt to go outside to take the Power Armour, the game either immediately CTDs or after a few seconds. Same issue with my previous save, except here it happened in the Vault you save Nick Valentine from, when attempting to leave with him.