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Delete the old reproc that you generated as well as the old bashed patch, then run loot and let it sort out your load order. Loot also reports a lot of interesting warnings, so be sure to look at those if you get any. After that, run wrye bash and generate the bashed patch again and make sure its at the end of your load order. After that you need to run the reproc.. Now that i look at it, are you running both SkyRE and Perkus Maximus? I was under the impression that perkus maximus was the successor, and you should only ever run one of those mods at a time.

You certainly can set it to autodetect, although i've read that it often doesn't detect the correct amount of vram, which causes the stuttering. This guide helps explain a lot of the settings: http://wiki.step-project.com/Guide:ENBlocal_INI/Memory "Users can try this feature; however, disabling it and setting the VideoMemorySizeMb parameter manually to fine tune the ENBoost settings is currently the recommended method."

You're regenerating the bashed patch and the reproc each time you change your mods around right? A lot of mods have a section called compatibility, if you didn't look at that you certainly need to. Freezing mid game sounds really bazaar, i've always had it crash when there was a problem. Are you able to open your console or the enb menu when this happens? Have you changed any settings in your ini under the papyrus section? It might be worth it to try the default ini with only the changes your mods require, which might be shadows, vsync and grass.

Oh i see, i was getting the two confused. I haven't gotten any infinite loading screens since i installed enb though, so it might not be necessary to install. Found a post relating, if you're using the latest skse i believe the default settings for the heap is already increased. http://enbseries.enbdev.com/forum/viewtopic.php?f=13&t=2729 "If you use safety load this fix will most likely help you to replace it and not have any side effects."

If you have the hardware to support lots of 4k textures, i'm sure enb can handle it. Safety load increases the size of the memory blocks, it does not offload some of the ram, nor does it handle it whatsoever. SKSE has a configurable way of doing this now, and i'm sure the op has skse installed considering all the other mods that are installed. (making safety load not required) I've been using auto unequip ammo for a few days alongside about 170 other esps without any crashes after fast traveling. The only crashes i encountered was while saving, and i believe i fixed that. I might try removing auto unequip ammo and see if that makes any difference, i know i didn't notice more crashes after it was installed.

If you're getting infinite loading screens you're probably not using an enb. The main reason to use an enb in skyrim is for the graphical improvements, but it also helps skyrim with memory management (enboost.) This guide should help you set it up: http://wiki.step-project.com/Guide:ENB If you don't have a lot of vram you might stutter a bit, but thats a hell of a lot better than crashing. You can avoid some of the stuttering by setting VideoMemorySizeMb to your actual vram. Be careful on the ReservedMemorySizeMb setting, i kept setting it too high and it was actually causing crashes. At the moment i have it set to 128.

Are you using any graphical mods? You could also be maxing out your vram, and if you're not using an enb, that would likely cause problems. Try standing still in game for a while and see if it simply crashes from that, preferably indoors like a player home. If it does crash then there might be a script causing it. If it doesn't then it's probably from loading stuff in game, which could be vram or a number of other things.

This guide might help you out: https://www.reddit.com/r/skyrimmods/wiki/beginners_guide Hopefully you're using some sort of enb, even if you don't want the effects from it. If you're not, it's very possible that you are maxing out your vram. Your bashed patch seems kind of high in your load order, i'd expect boss/loot to put it down at the bottom.

Dawnguard.esm Unofficial Dragonborn Patch.esp Dragonborn.esm Unofficial Dragonborn Patch.esp I'm not sure whats going on there but that might require some attention. It also looks like you're not using a bashed patched, i'm not sure if perma requires you to but i always generate one before creating the perma patch. This guide might be worth a look through: https://www.reddit.com/r/skyrimmods/wiki/beginners_guide It seems like you're running a few script heavy mods as well, i'm not sure what the limits are but i'm very cautious with scripts running constantly. About the saving, don't save over your old ones. I always create a new one and i've never had a problem with it, just delete the older ones when you're ready to.

I've ran into a few save crashes as well lately. What fixed it for me was waiting an hour in whatever location i was at and then saving. I've seen people recommend doing player.kill as well, probably worth a shot.