Hi, I am no Vortex user, but for me there would be some questions. Does this only happen when you start your game through Vortex and you can start it through the Fallout4.exe, Fallout4 Launcher, Steam (in case you have the Steam version) or the f4se_loader.exe (in case you have F4SE installed)? Are you on next-gen or pre next-gen with mods installed matching your game version? Especially F4SE and F4SE dependent mods. What happens when you try to start a completely unmodded game? Did you change the installation path or did you install the game in its default folders? Which mods do you use and are you inmidst a playthrough or do you try to start a new game with all mods enabled? With these information things might perhaps become clearer.