Jun and Marcy both become killable (no longer essential) after you complete the initial Sanctuary quest. So just put them where they will be easily killed ( on guard duty near a missile turret should do it) and get someone else to fish.
At 245 plugins, you are almost at the 255 cap. This is probably as far as you can go, hence the very random CTDs. Think about merging many mods together, reducing your plugin number by at least 50, but try for 100.
It's possible that you will meet her someday, I have met people that i had previously dreamed about. Also, she may be your feminine side, aiding you through dreams (i've had that too).
You have the Unofficial Skyrim Patch in the wrong place, and you don't have the Unofficial Patches for the DLCs at all. This could be your problem, download and install the Unofficial DLC Patches and place them in this order: Skyrim.esm Update.esm Unofficial Skyrim Patch.esp Dawnguard.esm Unofficial Dawnguard Patch.esp Hearthfires.esm Unofficial Hearthfire Patch.esp Dragonborn.esm Unofficial Dragonborn Patch.esp [Your other ESM files] HighResTexturePack01.esp HighResTexturePack02.esp HighResTexturePack03.esp Unofficial High Resolution Patch.esp [The rest of your mods]