I think I found a way to be able to edit your weapons for iron sights without having to close the game. At least I think so, this works for me. (Looks like you will need a good PC to do this, seems kinda intensive having nifskope and fallout 3 open at the same time) Small tutorial: -Load Fallout 3 (Windowed Mode) -Get in game -Place any weapon on a hotkey through the pip boy (Like Assault Rifle on 1) -Select the weapon you want to align, again via pip boy -Aim down the gun you want to align to get an idea of how it must be aligned -Press the hotkey for the weapon you hotkeyed earlier -ALT+TAB out of fallout 3 and load nifskope then open the weapon model for the gun you want to align (Make a backup just incase) -Make the needed changes in the mesh (translation, rotation, etc) -Save the updated mesh -Switch back to the Fallout 3 window -Equip the weapon you are trying to align via pipboy (do not use a hotkey for the weapon you are trying to align, otherwise the game won't load the updated model for some reason) -Aim down the sights and see your changes made without having to wait for Fallout 3 to load up all over again :) Idk if this has been posted in this article or not since I skimmed through and its 3:21AM here. :S Either way the information is there. ^^