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USLEEP should not be giving you CTD. It is likely something else. I would definitely suggest the clean install and make sure you are cleaning your master files correctly. Youtube should have some updated videos on how to do that.

I would try out this load order for your mods in the plugin menu: Skyrim Update Dawnguard <--- take note of this order for your .esms Hearthfires Dragonborn Unofficial Skyrim Legendary Edition Patch [Other .esms] HighResTexturePack1,2,3 Unofficial High Res Patch [utility Mods] (things like SKSE Scripts, UI Extensions, papyrus util) [All other .esps/mods] Modern Brawl Bugs Fix [Texture mods] (Mods that make skyrim look better) [body Textures/Meshes] (Mods that make NPC or player look better) FNIS [Animation Mods] XPMSE <---I would get the extended, which is the newer version of xp32 Alternate Start <---you should get this [Anything LOOT sorts after it] Make sure that you don't move/alter/delete any mods on an active save. Skyrim bakes scripts into your game, and if those scripts are no longer there, it could CTD.

Nothing in your load order is super bad. I still would change some things: 1. I would suggest using the Unofficial Skyrim Legendary edition patch and place it right after dragonborn.esm. 2. Also, take note that whenever you move/alter/delete a mod on an active save, it can cause random ctds as it tries to access those missing scripts. It's best to start a new game when changing mods around. Cleaning scripts does not work 100%. 3. Make sure your clean reinstall is actually a clean one: https://forums.nexusmods.com/index.php?/topic/906390-cleaning-skyrim-for-fresh-install/ 4. CCO Remade actually has two required mods that you should get. Read the directions and put them in the correct install order. 5. What may fix your problem is using the Crash Fixes mod. Make sure you carefully read the page and do what he says. Also, I'd suggest you get and use Alternate Start - Live another life. It helps further stabilize your game by loading all your mod scripts upon starting your new game, and it's great for testing. LOOT should have it sorted last in your load order.

Yeah, it is a 32 bit game being played on 64 bit systems. Aside from the normal bugs and development fails, it's bound to have issues. All the more now that we mod it; though some mods do bring stability to the game.

In addition to what Algabar stated, there are some optimization techniques you can use for windows 10 to help your game run smoother, but yeah, the game really is old. Hopefully in the few months SKSE comes out for SSE; though even if it does, most Bethesda games are just buggy as heck and in my opinion are not made well. https://steamcommunity.com/sharedfiles/filedetails/?id=500687692

1. I would use the unofficial high res patch if using the high res textures. 2. Make sure there are no errors in your FNIS as it loads. Sometimes it's easy to not see them as it scrolls and updates. 3. You have taken some crash fixing steps, but look at the Crash Fixes mod if you haven't and use that. 4. Ningheim states it requires XP32, but I'm not sure if you have it installed. I would actually grab the xp32 maximum skeleton extended and use that instead. Put it at the bottom of your load order. Here is the load order I suggest (letting LOOT have priority of course): Skyrim Update Dawnguard Hearthfires Dragonborn Unofficial Skyrim Legendary Edition Patch [Other .esms] HighResTexturePack1,2,3 Unofficial High Res Patch [utility Mods] (things like SKSE Scripts, UI Extensions, papyrus util) [All other .esps/mods] Modern Brawl Bugs Fix <---Get this [Texture mods] (Mods that make skyrim look better) [body Textures/Meshes] (Mods that make NPC or player look better) FNIS [Animation Mods] XPMSE Alternate Start <---Get this if you're modding. It helps load in scripts and you can still do vanilla start if you want. [Anything LOOT sorts after it] If you are using MO, make sure that your left pane is the same (for the most part) as your right in the above order. Then sort and apply with LOOT. That will sort the right pane. Then rearrange the left pane to match the right. Make sure that your overwrites are properly emptied. If you don't know how, Gopher on youtube has some good intro videos. Also, you can try a clean install. When installing your mods, generally armors and simple mods you can load mostly in, but for the bigger scripted mods that do a lot of things or add a lot of dialogue to NPCs and such, for those install only a few at a time and test your game for a good number of hours to see if it is crashing. https://forums.nexusmods.com/index.php?/topic/906390-cleaning-skyrim-for-fresh-install/ You can also optimize your game for windows 10 if you are using it: https://steamcommunity.com/sharedfiles/filedetails/?id=500687692

If you aren't using Crash Fixes, you may want to check out that mod. Also I would suggest getting XP32 Maximum Skeleton Extended since you have some mods that mess with the combat and such. Make sure that you don't alter/move/delete any mods on an active save. This can cause crashes. It's best to start a new game if you do. Since you are using mod organizer, make sure you understand the basics. Make sure you also have the left pane matching the right as much as possible.

Make sure that in your skyrim launcher, that you have your AA and AS filtering turned off. As a side note: What ENB are you running? Are you using more than one flora mod? Nothing particularly looks bad in your load order except that I would have the end of it looking like: FNIS [Animation Mods] XPMSE Alternate Start - LAL [Whatever LOOT puts after]

Well since you are using Legendary edition, I would get rid of your USKP and get the Unofficial Skyrim Legendary Edition Patch and place it after Dragonborn.esm. Other than that, there is nothing dangerous there. Your system should be fine, so what I'm thinking is that perhaps you didn't clean install? Try this: https://forums.nexusmods.com/index.php?/topic/906390-cleaning-skyrim-for-fresh-install/

I would suggest it be as close to the right pane as possible, but as for textures or some mods, you want them to have a certain priority. Whatever is lower on your list is higher priority, and thus will overwrite those things positioned above it. So whatever you want to have displayed in your files, have it lower. Other than that, most everything should be in the order it is on the right. Make sure your LOOT is up to date and is the newest version. I remember my old LOOT saying that, but I don't think my new one does. I could be wrong though.

Anything over 60 is hazardous. You can cap your FPS with http://www.nexusmods.com/skyrim/mods/34/? to stop at 58 or so. Also, if using windows 10, you can optimize your system for it. One of the weirdest things for me was the XBOX dvr for my computer was interfering with my skyrim fps; even though I had never used the stupid app nor activated it. https://steamcommunity.com/sharedfiles/filedetails/?id=500687692

1,2 Cool 3 I don't doubt that, but what I'm saying is, is that it's not likely sorted. You may have hit SORT, but you didn't likely hit APPLY after it. 4. In both the left and the right panes. These mods aren't sorted by LOOT, so you can move them where you wish, and they seem to do better at the end in the order I suggested. 5-8. Sounds good.

1. I would make sure your AOS is compatible with your other sound-based mods. Also check to see if your combat mods add sounds. They may not be compatible then. 2. You have ELE and ELFX? Two lighting mods are not good to have as far as I know. 3. Your Alternate Start is not at the bottom of your load order, which tells me you haven't sorted with LOOT. If you are using it, make sure you're hitting apply after you hit Sort. AS-LAL should be near last. Only your Bashed patch and DynDOLOD should come after it (other than what LOOT puts there). 4. Move all of your skeleton/animation mods to the bottom of your load order. I'll show you below. 5. I think all of your DynDOLOD files should probably be near to the end of your load order. Not sure on that, but I think so. 6. Brawl Bugs Fix should be lower in your load order. Not needed, but suggested by the mod author. 7. I believe there is a Cutting Room Floor patch for RS Children as well as a USLEEP patch for it as well. Check to see if you have these. So here is the load order I suggest to people often: Skyrim Update Dawnguard Hearthfires Dragonborn Unofficial Skyrim Legendary Edition Patch [Other .esms] HighResTexturePack1,2,3 Unofficial High Res Patch [utility Mods] (things like SKSE Scripts, UI Extensions, papyrus util) [All other .esps mods] Modern Brawl Bugs Fix [Texture mods] (Mods that make skyrim look better) [body Textures/Meshes] (Mods that make NPC or player look better) FNIS [Animation Mods] XPMSE Alternate Start [Anything LOOT sorts after it] Also, make sure that if using Mod organizer that your left side load order and right side match above, then when you get LOOT working, sort with it. It will organize the right pane, then match the left pane to the right pane. Also, make sure you know how to deal with your overwrites properly in MO If you aren't using it yet, check out the Crash Fixes mod. If using Windows 10, optimize your computer for the game: https://steamcommunity.com/sharedfiles/filedetails/?id=500687692

Whenever experiencing random CTDs, I generally look to either a Skeleton issue, a weather issue, a rain issue, a sound conflict, a memory issue, or a conflict in mods that isn't super prevalent or noticeable. Here is what I'd suggest: 1. Download Ragdolls and Force as well as XP32 Maximum Skeleton Extended. Some mods require these and don't mention it because they are so commonly used. I feel they add more stability anyways to the game. Place XPMSE at the bottom of your load order just above Alternate Start. 2. Your weather and lighting mods should be fine. It's generally when I see people install lighting mods that add weather.esp's from the lighting side that I see issues. 3. You aren't using any rain mods that can bog down your system, not that they always overpower systems. They just can cause CTD i've noticed if not installed properly. 4. It could be a memory issue. Go over to the Crash Fixes mod page and make sure you read it and install it. It can help stabilize your skyrim. Also, make sure that if using windows 10 that you are optimized for Skyrim: https://steamcommunity.com/sharedfiles/filedetails/?id=500687692 5. I don't see anything that conflicts so much. I would have suggested Open Cities if anything, but since you got rid of it, no biggie. I would suggest you start a new game and see if it still crashes after all such things. When modding, it's not abnormal to experience crashing every once in a great while, but frequently, no. 6. As for a sound conflict, I've experienced strange things with Sounds of Skyrim and other mods, but I've never used AoS. I'd imagine that it's possible to be conflicting with some mod somewhere, but I doubt it. You can check for conflicts in TES5Edit if you want. There should be youtube videos showing you how to do it.

1. Make sure your inconsequential NPCs mod is before any ETaC .esp that it adds. On his compatibility page for ETaC he suggests this. 2. Alternate start should be at the very bottom of your load order. If you aren't using LOOT, you should be; and if you are, then you aren't clicking apply after hitting SORT. 3. Your FNIS, animations, and XPMSE should be at the bottom of your load order above Alternate start. I'll demonstrate this below. 4. Your sexlab mods may not be compatible with others. Make sure you read those pages carefully. 5. Yes, your graphics setting should be set to whatever you are using I believe. I'm no expert in that area (let alone any area). So here is the load order I suggest to people often: Skyrim Update Dawnguard Hearthfires Dragonborn Unofficial Skyrim Legendary Edition Patch [Other .esms] HighResTexturePack1,2,3 Unofficial High Res Patch [utility Mods] (things like SKSE Scripts, UI Extensions, papyrus util) [All other .esps/mods] Modern Brawl Bugs Fix [Texture mods] (Mods that make skyrim look better) [body Textures/Meshes] (Mods that make NPC or player look better) FNIS [Animation Mods] XPMSE Alternate Start [Anything LOOT sorts after it] Sort your load order with LOOT and let it take priority of where it places your mods. This is just a guideline. Also, make sure that if using Mod organizer that your left side load order and right side match above, then when you get LOOT working, sort with it. It will organize the right, then match the left to the right pane. Make sure that when you make these or any changes to your Skyrim after moving/altering/deleting mods, you start a new game. Skyrim bakes scripts into your save and when those files go missing, it can cause crashes. Also, for stability sake, I would suggest you check out the Crash Fixes mod.