These last few days I attempted to use Vortex for modding my SkyrimSE instance by running Vortex in a Windows Virtualbox VM and sharing the relevant folders from the host to the VM.
Sadly, move deployment turned out to be highly unreliable since it seemingly arbitrarily decided to refuse installing some mod files but not others and making the deploy and purge mods buttons useless.
Vortex also complained about not being able to watch the files, so I presume that whatever code does the filesystem interactions for Vortex only has limited support for the shared folders presented to windows as network shares.
If move deployment could be made to reliably work with network drives/shares(?) then this VM strategy could be a good workaround.