If that didn't happened, you will run out of ammo, caps, junk and stuff. Yes, yes I would. That's what I want, a more survival based "realistic" wasteland. Additionally, there's the problem that When a cell resets, it resets nearly everything, take for example the satellite dish location near sanctuary, if you visit there after 2 weeks, and go to the Intel room, your character states -hmm need a terminal to open this"- then proceeds to open it with the intel key you looted last time you were here... ofc you can then explore deeper, and find a second intel key.. Dumb.