Edit: Aight boys, I SOLVED THE MATTER :D The problem was that the injector actually injected into Google Chrome (lol!) which I found out, when i tried to delete the injector.exe from /skyrim/. Windows told me that the .exe was still opened in Chrome, which I have always open. Anyways, the solution is simple. Just close Chrome before starting Skyrim. I feel pretty stupid now, but I am happy that I solved the issue. I just leave this post here, in case somebody has the same problem. OP: Hello, first of all I have to thank you for the great resource this forum has already been, I could find nearly every solution to my problems so far while the rest is being covered by the guys over at STEP. Anyways, I am stuck with this very issue and it really bugs me, after having enjoyed a working ENB. I am currently trying to set up RealvisionENB on my Laptop with a GTX850M, resulting in me using the injector-version of the ENB, because the wrapper version only works partially (I do not get any DOF f.ex.). Right now, the problem is, that the injector only injects once, right after installing the ENB + Preset. This means that I have to uninstall Realvision + ENB everytime before I start playing again. Sometimes it works twice but as soon as I hope the matter might be fixed now, it's not working again. What I do: Start MO Start the injector.exe via MO-Toolbar (just to be sure :D ) Start skyrim via SKSE_loader.exe I assume I have everything set-up correctly because it works. Once. Sometimes twice.