I think it is a matter of getting used to the layout again. Same when I first joined the wonderful community of nexus, I had to learn to understand and use the layout.
My positive experience is that the page seems to work slightly smoother, and I kinda like the new front page. There were some other smaller things that I forgot.
Only real problem that I have would be the strain it takes on my eyes. I need to focus on certain things little bit more than necessary so I sometimes get small headache.
(also the gray overlay thingy on top of mod thumbnail is quite distracting. Can that be turned off?)