Those HD texture packs makes game really more heavier than normally game is, and over 200 mods i´m pretty sure, your game is really really stuffed up and it cant handle it anymore, there might be about 20 mods with works together perfectly and and 180 which makes games to these problem, and what i check you specs you games require much more than that and if your HD textures are 4-8k then you need far more better computer, so try get rid of unnecessary mods, make list what are mods you can live with and what are mods you can live without. Like my game was fine couple days ago, but i´been trying to fix it now 3 days because of texture packs, its getting to much thing to handle which makes it to having issues.