D7Rock88

I had the exact same problem. Fallout 4 was not launching no matter what I did, however I did notice that a couple of times, mainly after restarting my computer, I did get it to launch once but never again. This told me that it wasn't a problem with mods or F4SE or anything else, but something about the update. Sooo I thought about it after a few hours of trying to get it to launch this morning and I realized the problem had to be the Creation Club part of the update. See, that thing is accessing the internet on Fallout 4 which for me Fallout 4 has never done before so my anti-virus was seeing that and shutting it down. Well that's the conclusion I came too anyway, I mean what else could it have possibly been? Turns out I was right, after manually adding Fallout 5 to my anti-virus's exceptions list the game started to launch. tl:dr Try adding Fallout 4 to your anti-virus's exceptions list. It worked for me, and it might work for you aswell.