Googerman101

I get the boot up screen but when I try and start up the game it just crashes instantly. Also tried open up Nexus Mod Manager, launch FO4, but only to the Setup screen where you can change your graphics options...don't actually continue your game. Then go back to the NMM and re-enable all mods under the Plugins tab (check all the boxes) for mods you want active). Then go back to the Fallout screen and launch the game. Had no issues running any of my mods until yesterday. Any ideas or do i need to delete all files and start over?