Crimson Tide causes save game corruption and bloat. Use dD - Enhanced Blood instead. I found that I got frequent CTDs with ELFX until I moved it to the very end of my load order. It doesn't change anything with SkyRe, so it works fine. Consider grouping the .esps to some of your other mods, like CoT, together in the load list, rather than several spots down, and in the proper order, where the main mod is first, followed by a DG patch, then a DB patch, then a HF patch, then any other patch. This also seems to help with stability. Lastly, try lowering your graphical settings by a tick.