I just ran into this problem. I use MO, SKSE, ENB, 200+ plugins. I use SaveCleaner, PDT_Wrapper and SaveTool.exe all the time to fix things, but no luck this time. It would crash after Waiting for a few hours (I was outside). I was trying to wait 31 days to fix another issue but it would crash seconds after the 31 day waiting was finished, with save-on-wait set to off. I disabled a merged patch I recently made, deleted an abundance of _APB bird spawning scripts and disabled that bird mod, Turned off Alternate Start from these suggestions, and also Levelers Tower since some scripts there looked funny. PDT_Wrapper kept showing me that some Vampire quest was broken too so that got me worried. After checking the Papyrus.0.log (C:\Users\yourname\Documents\My Games\Skyrim\Logs\Script) after crashing a few times, I saw Familiar Faces was having issues loading my past characters out of nowhere, and was the last thing to be displayed before the crash. Could have been from cleaning my earlier saves I guess. I haven't even used that mod in a longggg time. Turned off Familiar Faces (papyrus log will say something about MYC/Actor/yadayada in last few lines), and no more crash! Moral: when you're crashing mid-game, always check the end of the Papyrus log and turn whatever is there off asap.