Alright, this is happening to me now, unfortunately. As expressed in a previous post, I can load a past game save (just pure luck I had one sitting around). That save was at 4.6 Mb. I can load that game and then load any of my other saves from in-game. All my other saves are over 9MB. So, the theory that this has something to do with large game saves seems to hold true. I have plenty of RAM (12 GB) and a high end video card - disabled all mods and ran with vanilla *.ini and the problem persists. I didn't try uninstalling the game and deleting all references to it in the registry as suggested in a previous post. Nothing against that, it's just that thankfully I can still load my very old game save and get to my game saves from that one. There is also a thread in the elder scrolls community forums about this issue but no insight into a solution. In thinking back, I have started to notice longer loading screens after opening doors or fast travel. This is probably also connected to the large save file. Hopefully the issue is addressed soon. This workaround solution is nice but who knows how long that will last.