Yep. The DEF_UI mod was CTD my game right as a save was about to load. Removing it allowed my game to load. I also experienced my plugins randomly deactivating and me having to reactivate all of them. I'm not entirely sure what that is yet.
Vivec is my personal favorite. I can remember wasting god knows how much time just browsing through Jobasha's library in the upper foreign quarter. I really do miss this game.