I'm having a similar issue to this - I've tried disabling all mods (including Dawnguard and Dragonborn), but when I sleep and wake up in the Abandoned Shack, Astrid never starts talking and I can't move. Any ideas as to what I can do? Edit - Never mind. Used the console to add the key to my inventory, entered manually, killed someone, and the script moved on. Not going to delete this reply, though, just in case someone else has a similar problem in the future.