I have found a fix that workds 100% of the time for me. For me for some reason it deals with the amount of quick and auto saves i have. Before i even start up my game i go to saved folder and cut and paste my save files exept the latest one to a backup folder. For a good long duration it works fine. once i get a infinite load screen i close game and do same thing. i also have turned off auto saves but for some reason after certian times in game it will still auto save and i do not quick save at all, i just try and save through normal means as much as i can. everytime i do this though i get a good few hours of uninterupted gameing. hope this helps others.
