For steam users, who have are struggling with manually updating the app manifest the following workaround works too:
1: backup your entire Fallout4 folder from \steamapps\common\Fallout 4
2: let steam do the update
3: set the \steamapps\appmanifest_377160.acf file to read-only
4: delete the whole Fallout 4 folder from \steamapps\common\Fallout 4
5: restore your backup (you did make a backup in step 1 right?)
6: launch vortex, it will tell you that mod deployment is needed, do so, but choose "Use newer files"
7: welcome to the caveman club and have fun playing your old, outdated, un-updated, non-nextGen version of Fallout4