Permanent fix for crashing on my PC: It is related to auto-saves like gjm777 stated. However disabling auto-saving is insufficient (and not required; leave auto-saving enabled as it was). I noticed that once the game started crashing, if I fast-travelled to another location, it said "Autosaving" and after a few minutes in the new location it crashed. However after I rebooted and clicked Continue game, it started from my old location and not from the auto-save after I fast-travelled, which meant that the auto-saving failed completely and it subsequently crashed. So I fast-travelled to a new location and created a manual save (Escape->Save) and then quit to desktop. I then went to the "My Games\Skyrim\Saves" folder and deleted all the auto-saves and quick-saves and left only my manual save. Now when I continued playing everything worked fine including future auto-saves and it hasn't crashed in over 2 days. I had inadvertently done this 2 weeks ago while trying to clean all traces of the game and it started working properly back then, so it's worked successfully on two incidents. Basically: 1. Continue game 2. Fast-Travel to new location 3. Save game manually (Escape->Save) 4. Quit to Desktop 5. Delete all saves from "My Games\Skyrim\Saves" except your manual save. 6. Continue game.