As someone else stated, the game itself has problems which cause CTD's. Another reason for game crashing with mods can be your load order. I use a program called LOOT to sort my mods. https://loot.github.io/ This tool checks your mods for conflicts. https://www.nexusmods.com/fallout4/mods/2737/ You may also have a corrupted save so I use this one to check Saved Game files. https://www.nexusmods.com/skyrimspecialedition/mods/5031/ I prefer to copy the last saved game to the desktop before I run it in the FO4 saved games folder. I've never needed to revert back but it's always better to be safe.