Experiencing similar problem. Game ran fine on windows 7 , bought a new computer (Alienware Aurora R8 i9 9900k 4.7ghz,16gb ddr4 , 512gb ssd, 2 TB h/d, nvidia rtx 2080 w/8gb gddr6) and cannot get game to load from Steam. Tried with and w/o skse. At one point windows aid it was an incompatibility issue so I got them (chat) and they told me it was skse. but it will not start w/o skse either. Is there a problem between Steam and Windows 10, dunno ? Anyone else experiencing similar issues?