Ok got an odd issue here. I searched bud didn't find anything about a max number of mods but I have no other idea of what could be causing this. I have a lot of mods installed. Both large and small, but really the only large one I have is MMM and the official DLCs. Most are ether game tweaks to how in my opinion the game should have been or house mods in new cities. When trying to run all my mods at once I get an issue with the interface. I am not able to open the game menu by hitting esc the menu doesn't appear. I am not able to use quick save or quick load. The game will NOT save when I enter a new cell or a building but it will say that it has auto saved. This happens when ever I get over 219 mods. It doesn't mater if its an esm or a esp. It doesn't matter what kind of mod it is, a texture replacer for an item, quest tweak, or adds an item.... My pluggin list is as follows if its any help.... Fallout3.esm Anchorage.esm ThePitt.esm BrokenSteel.esm PointLookout.esm Mart's Mutant Mod.esm CRAFT.esm Ammo Bench.esm Selected Containers Respawn.esm EnhancedChildren.esm Unofficial Fallout 3 Patch.esp Alternate Start - Roleplayers.esp Delay ThePitt + Anchorage.esp DelaySteel.esp delaypl.esp Clothed American Soldiers.esp Clothed Sarah Lyons.esp Mart's Mutant Mod.esp Mart's Mutant Mod - Hunting & Looting.esp Mart's Mutant Mod - Natural Selection.esp Mart's Mutant Mod - No Ghoul Raise.esp Mart's Mutant Mod - DLC Anchorage.esp Mart's Mutant Mod - DLC The Pitt.esp Mart's Mutant Mod - DLC Broken Steel.esp Mart's Mutant Mod - DLC Point Lookout.esp Fellout-Full.esp Fellout-Anchorage.esp Random Encounter U54 Human Bomb fix.esp MissingUniqueWeapons-Enhanced.esp MissingUniqueArmorClothing-Enhanced.esp CharacterTraits Anchorage Compatible.esp Selected Containers Respawn.esp Selected Containers Respawn - Emptied Trash Cans in Player Homes.esp ShellRain.esp SP_EFECT - Luck - Triple Effectivness.esp UPP - Experience Perks.esp UPP - Original Perks.esp UPP - Quest Perks.esp SP_EFECT - Bloody Hell - Higher Blood Decal Count.esp SP_EFECT - Bloody Hell - Double Decal Duration.esp SP_EFECT - Combat Elevation - Stronger Sneak - 3x.esp SP_EFECT - Bloody Hell - Double the Dead.esp SP_EFECT - Guard Response - 2.esp SP_EFECT - Death Reload Time - 30s.esp SP_EFECT - More Debri.esp Ammo Bench - Artisan.esp Improved Explosions v1.3.esp Easier_hacking_5_8.esp Improved Turret Hacking.esp Directional PipLight HDR.esp Fellout-pipboylight.esp Lamplight Backdoor Exit.esp Little Lamplight Front Gate.esp NPCs Sleep Tighter.esp ReneersRadioMod.esp ReneerShootEmInTheHeadMod.esp PreWar Book Titles and Perks.esp mz safeWading.esp MS11fix.esp firelance-quest.esp SniperZooming.esp Haldurs Improved Workbench.esp CRAFT - Activation Perk.esp Stealthboy Recon Armor - CRAFT.esp CRAFT - Workbench and Crafting Expansion combined.esp Cryo Weapons - Vanilla.esp Molotov Cocktail - CRAFT.esp PlasmaProjectileFastenerV1.esp Accessorized Helmets and Mask.esp JL121RCAltDoor.esp HaroldFireFix-All.esp US Army Power Armor Fix by Vergel.esp PowerArmorTraining.esp PowerArmorTraining_MedicArmor.esp FeminizedPowerArmor.esp PowerArmorTraining_Linden.esp Power Armor Helmet Light HDR.esp Operation Anchorage Equipment Fixes.esp OAFeminizedPowerArmor.esp TPFeminizedPowerArmor.esp Tesla_Backpack.esp Improved Frags.esp Item Weight Overhaul.esp WeightAmmo.esp FF_InteractiveBobbleHeads.esp FF_WonderMeatMaker.esp FF_PortableLabInfirmary.esp PortableCamp NewWave.esp Portable Turrets.esp Enclave Theme.esp RangerHelmet.esp Combat Armor Helmets Included 2.esp The Car Fort With Quests.esp JunkShop.esp FalloutShelter.esp MaintenanceShed.esp Echo_OutpostV2.esp GrayditchApartment.esp Old Military Bunker 1.3.esp Tenpenny Suite.esp RivetCityConApt V2_1.esp The Bunker.esp FruitTrees.esp OasisSafeWater.esp Megaton Outskirts.esp BuildableBots v0.3a.esp PersonalVertibird.esp cheaperhouseitems.esp MrLabTechnician.esp BM12PungaGardenPurchasable.esp FusionGeneratorStation.esp CanterburyCommonsEmbiggened.esp Broadway_cinema.esp DCInteriors_Georgtown.esp StimpackLootChanges11.esp gender perks unlocked.esp Metalux Factory.esp Meresti Metro Station Entrance.esp Megaton Tweaks.esp Fort Constantine Hard Locks.esp TheManBehindTheCurtain.esp MoreMapMarkers.esp Nuka Cola Refill Stations.esp TL_Color.esp Pinkerton Unlocked.esp TakingOutTheTrash.esp kikaiEquipment.esp Arefu_Expanded.esp Enclave Radio Fix.esp richvendors.esp vault92 fix.esp Vault87EntryFix.esp Vault87CompanionFix.esp doctorli_glasses.esp [CLO]BlackWolf Backpack.esp Backpacks - SedPL.esp T51b+.esp YK40 Pulse Pistol.esp DN_RadicalRadSuits.esp LightweightFoodSanitizer.esp royphilipsevilwmask.esp solarcharger.esp Grenade Launcher.esp nightvisiongogglesft.esp NightvisionGoggles(Powered).esp Navik_Glasses_Buff.esp Ghoulbear.esp antagonizer.esp mechanist.esp FlareGunBasic.esp LighterFissionBattery.esp Echo_BatteryCharger.esp Echo_UseBothGloves.esp RD_ElderLyonsRobe.esp WeaponModKits.esp WeaponModKits - ThePitt.esp WeaponModKits - OperationAnchorage.esp Energy skill Gatling Laser.esp Gauss_tweek.esp GaussCompleteBeta.esp Tranquilizer Weapons Anch.esp Explosive Entry.esp PlasmaRifleAwesomefied.esp Lesko's Lab Coat Loot.esp 3EFfaceplate.esp QuantumPipeV2.esp STR+MEDBOBBLEHEADMOVE.esp poolballs.esp FollowerAmata.esp FollowersRelax.esp Better Caravans.esp Better Companions Ess.esp factions.esp LJD_ENCLAVE ENABLED.esp Faces_Of_Fallout.esp Project Beauty.esp LittleLamplightStrikesBack.esp KillableKidsNormalHealth.esp outcast_comp.esp Outcast Scribes03.esp FacesoftheOutcast.esp FotE RavenRock.esp FotE Exterior NPC.esp T3T_OutcastTechSupport.esp Reilly's.esp SeducingWomen.esp Named Wasteland.esp Enable All Hair and HeadParts.esp YearlingsGlasses.esp Less Useless Karma Gifts.esp Sensible Dismemberment Lite.esp Lil_Critters.esp Missing abilities.esp AmplifiedCrippledEffectsV1-0.esp Less addiction odds.esp Higher Jump.esp Cliff's_Sellable_Body_Parts.esp BetterFood.esp FalloutFood.esp Rename Food.esp FIN-NWSeneca.esp GaryHoloTape.esp Wasteland Mercs 2.0 - no child left behind edition.esp NoRadsVanilla10.esp ReneerInvisibleKarmaMod.esp DarNifiedUIF3.esp WastelandMastery.esp Console Key Binder.esp AcquiredImmunity.esp SD Theme Swap.esp Deadly Radiation.esp RRRU +4.esp Magic Fingers Perk No Karma.esp Salvagable cars.esp GeneratorSound.esp NoTheftComments.esp Wasteland Travel Caravans.esp FungusDeal.esp BusworldV1.05.esp