I am having the same exact problem as duckz and I can assure you all it is NOT a hardware issue. I have a quad-core with 8GB of RAM and a 1GB ATI graphics card. I normally run 200+ mods and have never had a screen crash like this or even as much as a persistent CTD issue. I started experiencing the issue sometime late last week after Steam automatically loaded some update to Skyrim. I was playing late at night and had to shutdown my game for a while. When I returned to my game, I noticed the auto-update downloading on Skyrim under my Steam Library tab. Once completed, I started Skyrim and BOOSH my monitor shuts down, reads "NO SIGNAL" and the background music in Skyrim starts skipping like crazy. I have disabled every single mod I have and started a new game and still get the black screen of death. I have deleted all left-over scripts from uninstalled mods, replaced the necessary modded scripts with the originals I backed up, I have completely disabled and deleted ENB and corrected the .ini settings... I have tried everything I can think of, short of uninstalling Skyrim and then reinstalling... *UPDATE* Well, I completely uninstalled Skyrim and then reinstalled... so far no black screen crash and I'm running about 100 mods still. When all else fails, tear it down and start again :)