I don't see why you couldn't, as long as (on your desktop) you put the files where the game or your mod manager wants them.
I don't use Vortex or NMM myself -- or have Fallout 4 -- but from what I can find, the default location for Vortex's downloads is %APPDATA%\vortex\downloads\<game name>\. So unless you moved that somewhere else... 🙂
EDIT: replace <game name> with whatever it calls its Fallout 4 folder -- likely fallout4 (though again, I don't have it to check).
