I've updated the game in the past and outside of having to wait for a F4SE update, I haven't had any other issues. I also have some old mods installed that work just fine despite not being updated in years. Most of my mods are mods that add weapons or power armour. I have some gameplay altering mods, but most of them haven't been updated since 2016/2017 and work just fine, so I'm curious as to what mods, aside from F4SE, will need to be updated after the next gen update.