Crashes very frequently right at the beginning while on the wagon, but occassionally can play for awhile. Just got the game and let it finish patching up, not using any mods aside from the official DLCs (disabling them doesn't help at all). Windows XP Professional, Service pack 3. 3328 MB RAM, AMD Athlon II X2 235e Processor, dual-core 2.7 GHz. Nvidia Geforce GTX 570 with latest drivers.