I found that with one of the mods I had that added the black cowl, (conceal's you identity) would cause serana not to talk to me. only her though, didn't have any problem's with other npc's. she was my only follower at the time, so I'm not sure if that's the problem with other followers or not, or if that's the problem at all. so if you are using that hood, or the enchantment onto another hood, it would be worth it to try taking it off and see if that works. not much of a fix, but that was my problem. hope it helps. :blush: