Wouldn't call it high-end, I mean a b250 board with kaby i7k ( u know, u can't use the intel k features on a b250 board.. ), a 1060 with a 60hz screen... That's just a strange mix. The config sounds like a typical pre-built. If so, chances are high u have a low-end/crap psu inside.. Ugh... Anyway, it should run with more fps, since u had no probs before. So, what mods have u removed and how? Low fps everywhere ? Also make sure (so far) all your mods are compatible with each other. Also monitor your sys usage while playing fo4, like ram, vram and so on. Worst case, perform a clean fo4 install... And what exactly ?