I initially experienced CTD on game launch (at the Bethesda logo) after the install of the new version yesterday. After someone reminded me that CTDs upon game launch are usually load order or dependency issues, I ran Loot, which listed 1 mod I use (that is a dependency for many other mods) as missing. NMM listed this mod as correctly migrated and reinstalled. I uninstalled, deleted, re-downloaded and reinstalled that 1 mod (plus FNIS) and my problem was solved. Although I have not yet experimented with multiple profiles, my game is currently running normally. I have to reiterate the statement made several times by others that the reason many of us blindly accept new NMM versions without research (and without much thought) is due to the level of trust that has been earned after going through several NMM upgrades with minimal issues. That trust is a compliment to everyone that has worked behind the scenes to make NMM such a valuable, easy to use tool. You guys provide us a service that enhances our game play. You do a stellar job, and most of us appreciate the hard work you put into making NMM work so well. While I understand the frustration of those who suffered (and continue to struggle) with larger issues than I experienced with this latest version, I, for one, am grateful for the tool and for every soul who works hard to make it available to me.