Using Open Cities with HighResTextures seem dangerous to me. I'm not sure tho. But then again, you have a high-end pc. Just to be sure, try disabling them. Also try using TES5Edit on dirty mods. When I use LOOT with MO it warns me of ITM records. Even the official DLCs have them. I remember it caused some crashes for me but when I cleaned them with TES5Edit, the crashes stopped.