I am so frustrated by this. My game is heavily modded, but normally runs smoothly. Then they drop this patch on us and everything is borked beyond recovery. I spent 2 days updating everything & then deactivating mod after mod, trying to get past the ctd at the opening window. Finally found the culprit was a conflict with the minutemen overhaul, got it fixed and reloaded, player happily for a couple of hours til I almost have the visitor's Center in Far Harbor ready for occupation, and realize my build menu has somehow lost the furniture tab, so I can't put beds in. After all day of trying to find & fix, I'm about ready to scrap the whole thing. I have tried rolling back a few hours of saves to no avail. Finally able to get a full menu again by going all the way back to start, before I installed SKI. Since uninstalling such core mods is almost certain to cause permanent issues, looks like I have no choice but to toss out weeks of game progress, start over with SKE instead, and try to work out a solid mod order under that. That will maybe be good until the next Beth patch... Maybe I'll just go back to Skyrim/FONV until they decide this is stable.