This thread will list the common issues along with the solutions/workarounds. These problems are most often not a fault with Vortex but represent common configuration errors.
Vortex 1.8+ on Windows 7/8/8.1 -
The procedure entry point DiscardVirtualMemory could not be located in the dynamic link library KERNAL32.dll
Microsoft .NET - Check Failed (Vortex 1.6.7+)
Plugins Section not showing (Bethesda games)
Vortex is only showing a white screen
Extension fail