A corrupted save game cannot be detected simply by toggling your mods on and off. If a save appears to be corrupted, I would just suggest deleting it completely. The missing content message you get when you load a save is just because one or more mods that were active when the save was made, are no longer active or present. If you have recently updated any mods before you started playing again, check the readme files to see if the author recommended doing a clean save or not. If you don't know how to do that, just ask. You have a large number of mods that I am not familiar with, so I have no idea if any of them are .esm or .esp files. It is important to have all your .esm files loaded before your .esp files. The order in which each of these is placed is also important: files will override the ones above them in load order. I do see you have some FWE plug-ins but not the FWE .esm or .esps. If you do not wish to use FWE, uninstall those plug-ins. They are unneccessary and will affect your game in a small, but negative way. Speaking of FWE, even if you are not interested in using it, I recommend going to the mod's page and clicking on the readme link. That particular readme is a bit out of date, but the section on Load Order will help you arrange your's better. Follow this link for FWE http://www.fallout3nexus.com/downloads/file.php?id=2761 When it comes to using FO3 Edit, I don't use the Master Update function, I make what is called a Merge Patch. A Merge Patch helps your mods run more smoothly together. After you have your load order more or less fixed, run FO3 Edit: it will either complete processing or find an error and stop. If it finds an error, it will tell you so. Correct any errors it finds, then run it again until all errors are fixed. Then right-click in the left hand window and select Create Merge Patch from the drop down menu. Enter a name for this and hit ok. You will know when this is finished. Exit FO3 Edit. The next time you run FOMM, you're Merge Patch plug-in will be at the very bottom of the list. If it isn't checked, check it before you start playing. Also, leave it as the very last entry, unless you have a mod that states otherwise. You should do this everytime you install or uninstall a mod. Updating mods that do not require clean saves should not require this. Before you do, though, uncheck your Merge Patch in FOMM, then delete it from your FO3 data folder.