I'm fairly new to Skyrim modding myself but I've put the effort into reading a lot. I would have liked a heads-up early on so here's what I'm seeing so far. It seems you are still unsure about which mods to have and with the beasty machine you have I would forget about Skyrim and just use Skyrim SE. I doubt you would miss the SKSE-based mods as it seems you are looking more for meshes, textures, reshades and maybe ENB's for the best-looking game possible. SE is 64-bit so it can access more main memory, has higher res textures and is much more stable (probably from having no memory issues, possibly because no SKSE-based mods yet). From comments I've read quite a few people are now completely uninstalling classic Skyrim (aka LE, Legendary Edition or Oldrim) and just using SE. If you go this route, the best thing I can suggest is to use the SEPTIM guide found here That guide takes you from start to finish. Make sure you check the comments section, over 4000 so plenty of people are there with problems and solutions. Also check the LOOT posts for people's load orders. Learn to use the search function if you have issues, it helps. The SEPTIM guide is 6 months old so could use an update but if you have a look through the first few pages of posts there you can find links to other people load orders which show more or different mods. Now, reviewing your list of mods I do see sexlab framework which I assume is SKSE-based. If that's important to you then you may want to stick with Oldrim and follow the info in DaddyDirection's post. At this point I would say start again with SE, clean install and follow that guide. Expect issues as mods change and conflicts can happen. But search for answers before asking. Most of all, learn, learn, learn.