JungleRhino

This is incredibly frustrating indeed. Also note that there appears to be a bug that if you have multiples of a weapon (i.e. 3x hunting bows in your inventory) that you assign a hot key to the game forgets the assignment after you have used it once. At least this is the case for bows. Interface in general = terrifail

I had exactly the same problem, I'm running Win7 64 with HD6870 and I had everything cranked up to Ultra. Game ran fine but kept crashing, wound back the draw distance, dropped Ansio to 8x and switched to FXAA (which I think looks better as it blurs out all the terrible textures). Running pretty stable now. Also try taking a few carriage trips around to some geographically distinct locations i.e. Markath to Whiterun I think that may bring it on as it loads a whole bunch of new textures up? So yeah basically looks like a definite software issue with video resources - my system can play Shogun2 all day long without blinking so I'm confident my hardware has nothing to do with it.