When you say "not able to interact", do you mean that when you try to open a door for instance, you can no longer do that? If so, do you have any UI, "user Interface" mods installed. Adding the lines bInvalidateOlderFiles=1 sResourceDataDirsFinal= to your StarfieldCustom.ini wont cause any issues in itself and is actually one of the first steps in setting up your game to load loose files for modding. What was discovered with the last update, was that certain UI mods like Star UI Inventory, Enhanced Healthbar, Scanner Uncumbrance Display and other UI mods were causing the activate key to go dead. Some of these mods have been updated, some may not have.