Pickysaurus

Delete the file and redownload it, Vortex should be prompting you to do this.

Extensions -> Show Bundled -> Verify Oblivion is active, you may have disabled it.

Log out and back in.

Unless you have another app installed windows will remember that Vortex was the NXM:// handler. This is a config problem in whichever other app you're trying to use.

https://forums.nexusmods.com/index.php?/topic/12891273-common-solutions-megathread/&do=findComment&comment=127008210

This is covered in the pins https://forums.nexusmods.com/index.php?/topic/12891273-common-solutions-megathread/&do=findComment&comment=124189977

You will need to move the mod staging folder (Settings -> Mods) to your F drive then click deploy in the mods tab

Please see this issue, 401 and 403 are very similar so it's almost certainly the same problem https://forums.nexusmods.com/index.php?/topic/12891273-common-solutions-megathread/&do=findComment&comment=127008210

There is a pinned thread with common solutions in it: https://forums.nexusmods.com/index.php?/topic/12891273-common-solutions-megathread/&do=findComment&comment=127008210
 
We're aware of this problem and it should be fixed in the next major release.

This is covered in the pinned thread. https://forums.nexusmods.com/index.php?/topic/12891273-common-solutions-megathread/&do=findComment&comment=127008210
 
I have hidden several needlessly rude/confrontational comments from this thread and locked it.

Follow the instructions in the message or check the pinned solutions post.

This is answered in multiple other threads on this forum and our FAQs: https://modding.wiki/en/nexusmods/collections/FAQ#why-do-i-as-a-free-user-have-to-go-to-each-mod-page-individually

Plugins and mods are different, you need to managing plugins under the "Plugins" tab using the "Manage Rules" and "Manage Groups" options on the toolbar.

Vortex might need an update to support the full release of BG3

Edit the tools on your dashboard and either update or remove the xEdit one

Try renaming the %appdata%\Vortex folder to something else and see if it starts up. If it works, your Vortex state (the internal settings and database) was corrupted.

If you're using the beta of Vortex and it happens around every six hours this is a known issue and should be fixed before the beta goes to stable

You need to go to Settings -> Mods and moving the "Mod Staging Folder" to the same HDD as the game.
 
Clicking "Suggest" next to this field will likely fix it.

Go to Settings -> Download in Vortex and toggle the option to handle links off and on

Try this solution https://forums.nexusmods.com/index.php?/topic/12891273-common-solutions-megathread/&do=findComment&comment=124190193
 
It sounds like your .NET install is broken.

To completely start over you can delete the "Vortex" folder under "%Appdata%" from there you might want to use the "Suggest" options for both the downloads and staging folder locations.

If the plugins don't show in the plugins tab of Vortex then either your mods haven't deployed (check the notifications) or the mods don't have plugins.

They're not unnecessary or they wouldn't download automatically. It's much like Windows Updates. Some of them fix features you'll never use but improve the overall stability and quality of the app.

https://modding.wiki/en/nexusmods/collections/FAQ#why-do-i-as-a-free-user-have-to-go-to-each-mod-page-individually

Please check the pins or search the forum before posting. It's answered in the pinned post https://forums.nexusmods.com/index.php?/topic/12891273-common-solutions-megathread/&do=findComment&comment=124189977