I have been using vortex for about 2 months now with Skyrim SE, before I used Mo for Oldrim for about 3 years give or take.
I enjoy vortex the problems I have had so far were ether user error, or quality of life.
Though I do wish there were an option to check for external changes. [i might just be an idiot though] ;p
Ie (update fnis to save the changes I have to enable a fake mod folder and when it deploys vortex checks for external changes I save... Then disable the fake mod) aka quality of life.
I guess In the end it all comes down to preference.
The version I currently have in use is v0.15.9. Though I only have 85 mods in my current load order compared to my Oldrim 164 mods.
