Vortex is amazing, and here's why. I've been using mods for a long time, started using them with Morrowind way back when. That is to say that I'm not a dolt when it comes to modding. I installed Vortex just yesterday and went through reinstalling all my mods for both Skyrim and FO4 (that's a LOT of mods). Amazingly, and this seems like magic to me, I started up FO4 and everything worked - no weird notifications or glitches. What is even more amazing is that I discovered some mods that I had thought were installed but were not working properly (or at all). With NMM I had to also use LOOT and some other things and I was never sure of what was working. The mod list in Vortex shows me dependencies, conflicts and all sorts of other things.
Thank you devs for making an often convoluted process much easier :D
