Hi Instanthit, With your setup you should be able to run 2k textures, any ENB, and a myriad of over mods without issue. I use Opethfeldt's v7.3 ENB. Opeth says its intended for Vanilla Skyrim and he doesn't support Climates of Tamriel or any other lighting / atmosphere mods. That being said, below is MY setup (and I humbly think I've achieved something photorealistic): http://imgur.com/a/4jMyH#0