After all the fixes that didn't work what DID work was what someone else suggested elsewhere. To be sure the issue was:
After the recent update, the game no longer loaded mods. Going to Vortex, I got a "Cannot read .pak files" error. I reinstalled LS/Lib to no avail, continued to get the error. Updating Windows runtime to version 8 was supposed to fix this. It seemed to as I no longer got the error. However, no matter how many times I deployed the mods, the game would not load them.
The fix was: Delete everything in the game mods folder (not mod staging folder). Re-deploy in Vortex. Fix any remaining issues (I have one mod that likes to uninstall somehow) by reinstalling any missing mods, then redeploy, and the game is working. I hope this fix works for you!
In summary:
Step 1: Download and install .Net Framework v8 for Windows (or your device) https://dotnet.microsoft.com/en-us/download/dotnet/8.0
Step 2: Delete everything from mods folder (opened using the top menu on Vortex)
Step 3: Redeploy and reinstall any missing mods. Redeploy.
Step 4: Play the game!