I'm also having this, for the first time ever, after coming back to Skyrim. I've been playing the game on this same laptop since release, and at times much more heavily loaded down with mods than it is now. I've had CTDs before; they're nothing new, but this is altogether different. In my case, though, the crash is always caused by one specific thing: pressing "Continue" on the main menu instead of manually loading a game. My crashing is also much worse: I don't crash to desktop, BSOD, or anything of that note. My laptop instead instantly shuts off, do not pass go, do not collect $200, etc. I've basically trained myself never to use the "Continue" option because I rather don't fancy having to buy a new hard drive thanks to Skyrim insta-killing everything.